The activation of leukocytes by bacterial cell wall lipopolysaccharide (LPS) contributes to the pathogenesis of septic shock. It is well established that, in the presence of plasma LPS‐binding protein (LBP), LPS binds with high affinity to CD14. The binding of LPS to CD14 has been associated with the activation of cells, although available evidence indicates that CD14 itself does not transduce intracellular signalling. The physiological function of this interaction is to promote host defense mechanisms of cells to combat the infection (...) and clear LPS from the circulation. At higher concentrations of LPS, however, the activation of cells can take place in the absence of LBP and CD14, presumably through a distinct low‐affinity signalling LPS receptor. On the evidence published by us and others, we propose that in neutrophils, and possibly other leukocytes, L‐selectin can act as a low‐affinity LPS receptor. (shrink)

[Michael Friedman] This paper considers the extent to which Kant's vision of a distinctively 'transcendental' task for philosophy is essentially tied to his views on the foundations of the mathematical and physical sciences. Contemporary philosophers with broadly Kantian sympathies have attempted to reinterpret his project so as to isolate a more general philosophical core not so closely tied to the details of now outmoded mathematical-physical theories (Euclidean geometry and Newtonian physics). I consider two such attempts, those of Strawson and (...) McDowell, and argue that they fundamentally distort the original Kantian impulse. I then consider Buchdahl's attempt to preserve the link between Kantian philosophy and the sciences while simultaneously generalizing Kant's doctrines in light of later scientific developments. I argue that Buchdahl's view, while not adequate as in interpretation of Kant in his own eighteenth century context, is nonetheless suggestive of an historicized and relativized revision of Kantianism that can do justice to both Kant's original philosophical impulse and the radical changes in the sciences that have occurred since Kant's day. ***********[Graham Bird] Michael Friedman criticises some recent accounts of Kant which 'detach' his transcendental principles from the sciences, and do so in order to evade naturalism. I argue that Friedman's rejection of that 'detachment' is ambiguous. In its strong form, which I claim Kant rejects, the principles of Euclidean geometry and Newtonian physics are represented as transcendental principles. In its weak form, which I believe Kant accepts, it treats those latter principles as higher order conditions of the possibility of both science and ordinary experience. I argue also that the appeal to naturalism is unhelpful because that doctrine is seriously unclear, and because the accounts Friedman criticises are open to objections independent of any appeal to naturalism. (shrink)

[Michael Friedman] This paper considers the extent to which Kant's vision of a distinctively 'transcendental' task for philosophy is essentially tied to his views on the foundations of the mathematical and physical sciences. Contemporary philosophers with broadly Kantian sympathies have attempted to reinterpret his project so as to isolate a more general philosophical core not so closely tied to the details of now outmoded mathematical-physical theories. I consider two such attempts, those of Strawson and McDowell, and argue that they (...) fundamentally distort the original Kantian impulse. I then consider Buchdahl's attempt to preserve the link between Kantian philosophy and the sciences while simultaneously generalizing Kant's doctrines in light of later scientific developments. I argue that Buchdahl's view, while not adequate as in interpretation of Kant in his own eighteenth century context, is nonetheless suggestive of an historicized and relativized revision of Kantianism that can do justice to both Kant's original philosophical impulse and the radical changes in the sciences that have occurred since Kant's day. /// [Graham Bird] Michael Friedman criticises some recent accounts of Kant which 'detach' his transcendental principles from the sciences, and do so in order to evade naturalism. I argue that Friedman's rejection of that 'detachment' is ambiguous. In its strong form, which I claim Kant rejects, the principles of Euclidean geometry and Newtonian physics are represented as transcendental principles. In its weak form, which I believe Kant accepts, it treats those latter principles as higher order conditions of the possibility of both science and ordinary experience. I argue also that the appeal to naturalism is unhelpful because that doctrine is seriously unclear, and because the accounts Friedman criticises are open to objections independent of any appeal to naturalism. (shrink)

[Michael Friedman] This paper considers the extent to which Kant's vision of a distinctively 'transcendental' task for philosophy is essentially tied to his views on the foundations of the mathematical and physical sciences. Contemporary philosophers with broadly Kantian sympathies have attempted to reinterpret his project so as to isolate a more general philosophical core not so closely tied to the details of now outmoded mathematical-physical theories (Euclidean geometry and Newtonian physics). I consider two such attempts, those of Strawson and (...) McDowell, and argue that they fundamentally distort the original Kantian impulse. I then consider Buchdahl's attempt to preserve the link between Kantian philosophy and the sciences while simultaneously generalizing Kant's doctrines in light of later scientific developments. I argue that Buchdahl's view, while not adequate as in interpretation of Kant in his own eighteenth century context, is nonetheless suggestive of an historicized and relativized revision of Kantianism that can do justice to both Kant's original philosophical impulse and the radical changes in the sciences that have occurred since Kant's day. /// [Graham Bird] Michael Friedman criticises some recent accounts of Kant which 'detach' his transcendental principles from the sciences, and do so in order to evade naturalism. I argue that Friedman's rejection of that 'detachment' is ambiguous. In its strong form, which I claim Kant rejects, the principles of Euclidean geometry and Newtonian physics are represented as transcendental principles. In its weak form, which I believe Kant accepts, it treats those latter principles as higher order conditions of the possibility of both science and ordinary experience. I argue also that the appeal to naturalism is unhelpful because that doctrine is seriously unclear, and because the accounts Friedman criticises are open to objections independent of any appeal to naturalism. (shrink)

In reply to Michael Bertrand, I clarify my view that the problem of physical evil is not an a priori problem but an a posteriori one.

It has been claimed that recursion is one of the properties that distinguishes human language from any other form of animal communication. Contrary to this claim, a recent study purports to demonstrate center‐embedded recursion in starlings. I show that the performance of the birds in this study can be explained by a counting strategy, without any appreciation of center‐embedding. To demonstrate that birds understand center‐embedding of sequences of the form AnBn (such as A1A2B2B1, or A3A4A5B5B4B3) would require not only that (...) they discriminate such patterns from other patterns, but that they appreciate that elements must be bound from the outside in (thus, in the above examples, A1B1, A2B2, A3B3, A4B4, A5B5 are bound pairs). This has not been shown in nonhuman species, and sentences with this structure are difficult even for humans to parse. There appears to be no evidence to date that nonhuman species understand recursion. (shrink)

Individuals of some animal species have been taught simple versions of human language despite their natural communication systems failing to rise to the level of a simple language. How is it, then, that some animals can master a version of language, yet none of them deploy this capacity in their own communication system? I first examine the key design features that are often used to evaluate language-like properties of natural animal communication systems. I then consider one candidate animal system, (...) class='Hi'>bird song, because it has several of the key design features or their precursors, including social learning and cultural transmission of their vocal signals. I conclude that although bird song communication is nuanced and complex, and has the acoustic potential for productivity, it is not productive – it cannot be used to say many different things. Finally, I discuss the debate over whether animal communication should be viewed as a cooperative information transmission process, as we typically view human language, or as a competitive process where signaler and receiver vie for control. The debate points to a necessary condition for the evolution of a simple language that has generally been overlooked: the degree of to which the interests of the signaler and receiver align. While strong cognitive and signal production mechanisms are necessary pre-adaptations for a simple language, they are not sufficient. Also necessary is the existence of identical or near-identical interests of signaler and receiver and a socio-ecology that requires high-level cooperation across a range of contexts. In the case of our hominid ancestors, these contexts included hunting, gathering, child care and, perhaps, warfare. I argue that the key condition for the evolution of human language was the extreme interdependency that existed among unrelated individuals in the hunter-gatherer societies of our hominid ancestors. This extreme interdependency produced multiple prosocial adaptations for effective intragroup cooperation, which in partnership with advanced cognitive abilities, set the stage for the evolution of language. (shrink)

The strong predominance of right-handedness appears to be a uniquely human characteristic, whereas the left-cerebral dominance for vocalization occurs in many species, including frogs, birds, and mammals. Right-handedness may have arisen because of an association between manual gestures and vocalization in the evolution of language. I argue that language evolved from manual gestures, gradually incorporating vocal elements. The transition may be traced through changes in the function of Broca's area. Its homologue in monkeys has nothing to do with vocal control, (...) but contains the so-called “mirror neurons,” the code for both the production of manual reaching movements and the perception of the same movements performed by others. This system is bilateral in monkeys, but predominantly left-hemispheric in humans, and in humans is involved with vocalization as well as manual actions. There is evidence that Broca's area is enlarged on the left side in Homo habilis, suggesting that a link between gesture and vocalization may go back at least two million years, although other evidence suggests that speech may not have become fully autonomous until Homo sapiens appeared some 170,000 years ago, or perhaps even later. The removal of manual gesture as a necessary component of language may explain the rapid advance of technology, allowing late migrations of Homo sapiens from Africa to replace all other hominids in other parts of the world, including the Neanderthals in Europe and Homo erectus in Asia. Nevertheless, the long association of vocalization with manual gesture left us a legacy of right-handedness. Key Words: cerebral dominance; gestures; handedness; hominids; language evolution; primates; speech; vocalization. (shrink)

Alexander Bird has a two-part argument to the effect that God could only have created a world without physical evil by changing either the laws or the initial conditions of the universe, and that no such world would be at all like ours: so God is not responsible for physical evil. I argue that both parts of his argument fail.

Political Theologies of Justice: Meritocratic Values from a Global Perspective Michael Puett In fourth century BCE China, a religious revolutionary named Mozi emerged. In opposition to much of the religious practices and assumptions of the time, Mozi announced that Heaven, the highest god, was a just and non-capricious deity who had created the world for humanity. As a just deity, Heaven rewarded good humans and punished bad ones. And Heaven charged humans with creating a political order that did the (...) same: Moreover, there are ways that I (Mozi) know Heaven loves the people deeply. It shaped and made the sun, moon, stars, and constellations so as to illuminate and guide [the people]. It formed and made the four seasons, spring, autumn, winter, and summer, so as to weave them into order. It sent down thunder, snow, frost, rain, and dew so as to make the five grains, hemp, and silk grow and prosper, and sent the people to obtain materials and benefit from them. It arranged and made mountains, streams, gorges, and valleys, and distributed and bestowed the hundred affairs so as to oversee and supervise the goodness and badness of the people. It made kings, dukes, and lords and charged them with, first, rewarding the worthy and punishing the wicked, and, second, plundering the metals, wood, birds, and beasts and working the five grains, hemp, and silk so as to make the materials for people's clothing and food. (shrink)

All of the chapters have been written especially for the book by the leading scholars in the field.Michael I. Posner is Professor of Psychology at the ...

Current phylogenies show that paired fins and limbs are unique to jawed vertebrates and their immediate ancestry. Such fins evolved first as a single pair extending from an anterior location, and later stabilized as two pairs at pectoral and pelvic levels. Fin number, identity, and position are therefore key issues in vertebrate developmental evolution. Localization of the AP levels at which developmental signals initiate outgrowth from the body wall may be determined by Hox gene expression patterns along the lateral plate (...) mesoderm. This regionalization appears to be regulated independently of that in the paraxial mesoderm and axial skeleton. When combined with current hypotheses of Hox gene phylogenetic and functional diversity, these data suggest a new model of fin/limb developmental evolution. This coordinates body wall regions of outgrowth with primitive boundaries established in the gut, as well as the fundamental nonequivalence of pectoral and pelvic structures. BioEssays 20:371–381, 1998. © 1998 John Wiley & Sons Inc. (shrink)

This article examines the anatomy and circuitry of skills that, like reading, calculating, recognizing, or remembering, are common abilities of humans. While the anatomical areas active are unique to each skill there are features common to all tasks. For example, all skills produce activation of a small number of widely separated neural areas that appear necessary to perform the task. These neural areas relate to internal codes that may not be observed by any external behavior nor be reportable by the (...) performer. There is considerable plasticity to the performance of skills. Task components can be given priority through attention, which serves to increase activation of the relevant brain areas. Attention can also cause reactivation of sensory areas driven by input, but usually only after a delay. The threshold for activation for any area may be temporarily reduced by prior activation . Skill components requiring attention tend to cause interference resulting in the dual tasks effects and unified focus of attention described in many cognitive studies. Practice may change the size or number of brain areas involved and alter the pathways used by the skill. By combining cognitive and anatomical analyses, a more general picture of the nature of skill emerges. (shrink)

Many of the most skilled and educated citizens of developing countries choose to emigrate. How may those societies respond to these facts? May they ever legitimately prevent the emigration of their citizens? Gillian Brock and Michael Blake debate these questions, and offer distinct arguments about the morality of emigration.

In our view, a central issue in relating brain development to education is whether classroom interventions can alter neural networks related to cognition in ways that generalize beyond the specific domain of instruction. This issue depends upon understanding how neural networks develop under the influence of genes and experience. Imaging studies have revealed common networks underlying many important tasks undertaken at school, such as reading and number skills, and we are beginning to learn how genes and experience work together to (...) shape the development of these networks. The results obtained appear sufficient to propose research-based interventions that could prove useful in improving the ability of children to adjust to the school setting and to acquire skills like literacy and numeracy. (shrink)

Research in cognitive neuroscience now considers the state of the brain prior to the task an important aspect of performance. Hypnosis seems to alter the brain state in a way which allows external input to dominate over internal goals. We examine how normal development may illuminate the hypnotic state.

In this article I discuss the advantages of a theory of political representation for a prag- matist theory of (global) democracy. I first outline Dewey’s disregard for political rep- resentation by analyzing the political, epistemological and aesthetic underpinnings of his criticism of the Enlightenment ideal of democracy and its trust in the power of the detached gaze. I then show that a theory of political representation is not only com- patible with a pragmatist Deweyan-pragmatist perspective on democratic politics but also (...) that Dewey’s concept of “publics”, if applied to contemporary circumstances of globalized politics, requires such a theory. I suggest a pragmatic theory of political rep- resentation that combines elements of Dewey’s aesthetics, particularly his own theory of vision, with Michael Saward’s conception of representative claim-making into the notion of aesthetic democratic representation. (shrink)

This volume explores how functional brain imaging techniques like positron emission tomography have influenced cognitive studies. The first chapter outlines efforts to relate human thought and cognition in terms of great books from the late 1800s through the present. Chapter 2 describes mental operations as they are measured in cognitive science studies. It develops a framework for relating mental operations to activity in nerve cells. In Chapter 3, the PET method is reviewed and studies are presented that use PET to (...) map the striate cortex and to activate extrastriate motion, color, and form areas. Chapter 4 shows how top down processes involving attention can lead to activation of these same areas in the detection of targets, visual search, and visual imagery. This chapter reveals complex networks of activations. Chapters 5 and 6 deal with the presentation of words. Chapter 5 illustrates PET studies of the anatomy of visual word processing and shows how the circuitry used for generating novel uses of words changes as the task becomes automated. Chapter 6 applies high density electrical recording to explore these activations in real time and to show how a constant anatomy can be reprogrammed by task instructions to produce and perform different cognitive tasks. Chapter 7 shows how studies of brain lesions and PET converge on common networks underlying attentional functions such as visual orienting, target detection, and maintenance of the alert state. Chapters 8 and 9 apply the network approach to examine normal development of attention in infants and pathological conditions resulting from brain damage, and psychiatric pathologies of depression, schizophrenia, and attention deficit disorder. In Chapter 10, new developments such as functional MRI are discussed in terms of future developments and integration of cognitive neuroscience. (shrink)

ERP studies have shown modulation of activation in left frontal and posterior cortical language areas, as well as recruitment of right hemisphere homologues, based on task demands. Furthermore, blood-flow studies have demonstrated changes in the neural circuitry of word processing based on experience. The neural areas and time course of language processing are plastic depending on task demands and experience.